{
  "name": "Isotope Economy Knowledge Graph",
  "version": "2026-08",
  "license": "CC BY 4.0",
  "attribution": "Isotope Economy",
  "source": "https://www.isotopeeconomy.com/graph",
  "contact": "https://x.com/IsotopeEconomy",
  "description": "Structural dependency graph of isotopes, processes, facilities, companies, and applications in the isotope production and supply system. Orientation layer, not a capacity database.",
  "nodes": [
    {"id": "mo-99", "name": "Mo-99 / Tc-99m", "type": "Isotope", "val": 12, "note": "Diagnostic backbone. Global supply still depends on a small set of research reactors and processors. Outage risk is structural, not occasional."},
    {"id": "mo-100", "name": "Mo-100", "type": "Isotope", "val": 8, "note": "Stable molybdenum isotope used as target material in accelerator and alternative Mo-99 production routes."},
    {"id": "lu-177", "name": "Lu-177", "type": "Isotope", "val": 11, "note": "Therapeutic demand is rising faster than easy irradiation and radiochemical capacity. Reactor time and processing are the real constraints."},
    {"id": "ac-225", "name": "Ac-225", "type": "Isotope", "val": 10, "note": "Key alpha-therapy isotope. Multiple production routes exist, but scalable, reliable supply remains limited relative to clinical interest."},
    {"id": "ac-227", "name": "Ac-227", "type": "Isotope", "val": 8, "note": "Parent pathways relevant to Ra-223 and related alpha-therapy supply chains."},
    {"id": "th-228", "name": "Th-228", "type": "Isotope", "val": 8, "note": "Alpha-decay chain isotope relevant to Pb-212 generator concepts and targeted alpha research."},
    {"id": "pb-212", "name": "Pb-212", "type": "Isotope", "val": 9, "note": "Alpha-therapy related isotope in the lead/bismuth decay pathways. Production remains specialized."},
    {"id": "at-211", "name": "At-211", "type": "Isotope", "val": 8, "note": "Cyclotron-produced alpha emitter under active clinical and research development. Supply is highly specialized."},
    {"id": "ra-223", "name": "Ra-223", "type": "Isotope", "val": 9, "note": "Alpha-emitting therapeutic isotope used in targeted treatment pathways."},
    {"id": "y-90", "name": "Y-90", "type": "Isotope", "val": 9, "note": "Therapeutic isotope used in targeted radiotherapy and selected interventional procedures."},
    {"id": "sr-89", "name": "Sr-89", "type": "Isotope", "val": 7, "note": "Therapeutic strontium isotope used in selected bone-targeted treatment contexts."},
    {"id": "sr-90", "name": "Sr-90", "type": "Isotope", "val": 8, "note": "Parent isotope in Y-90 generator systems and a strategically watched fission-product pathway."},
    {"id": "re-188", "name": "Re-188", "type": "Isotope", "val": 8, "note": "Therapeutic radioisotope often discussed in generator and targeted therapy contexts."},
    {"id": "sm-153", "name": "Sm-153", "type": "Isotope", "val": 8, "note": "Therapeutic lanthanide isotope used in selected pain and targeted treatment applications."},
    {"id": "ho-166", "name": "Ho-166", "type": "Isotope", "val": 7, "note": "Therapeutic isotope explored in specialized interventional and radiotherapeutic applications."},
    {"id": "cu-67", "name": "Cu-67", "type": "Isotope", "val": 8, "note": "Therapeutic copper isotope paired conceptually with Cu-64 imaging. Production capacity remains limited."},
    {"id": "ga-68", "name": "Ga-68", "type": "Isotope", "val": 9, "note": "PET imaging isotope commonly obtained through generator systems fed by Ge-68."},
    {"id": "ge-68", "name": "Ge-68", "type": "Isotope", "val": 8, "note": "Parent isotope for Ga-68 generators. Specialized production underpins a large share of Ga-68 access."},
    {"id": "cu-64", "name": "Cu-64", "type": "Isotope", "val": 8, "note": "PET isotope with growing research and clinical interest. Capacity is limited relative to mainstream PET nuclides."},
    {"id": "zr-89", "name": "Zr-89", "type": "Isotope", "val": 8, "note": "Longer-lived PET isotope used in research and antibody imaging workflows."},
    {"id": "c-11", "name": "C-11", "type": "Isotope", "val": 8, "note": "Short-lived PET isotope produced on cyclotrons close to imaging sites."},
    {"id": "xe-133", "name": "Xe-133", "type": "Isotope", "val": 7, "note": "Noble-gas radioisotope used in selected diagnostic applications."},
    {"id": "tb-161", "name": "Tb-161", "type": "Isotope", "val": 8, "note": "Emerging therapeutic isotope. Production pathways are still scaling."},
    {"id": "i-131", "name": "I-131", "type": "Isotope", "val": 10, "note": "Therapeutic and diagnostic radioiodine with long-standing reactor-based supply routes."},
    {"id": "f-18", "name": "F-18", "type": "Isotope", "val": 10, "note": "PET imaging isotope. Short-lived supply depends on cyclotron networks."},
    {"id": "co-60", "name": "Co-60", "type": "Isotope", "val": 9, "note": "Industrial and medical radioisotope used in sterilization, processing, and selected therapy contexts."},
    {"id": "ir-192", "name": "Ir-192", "type": "Isotope", "val": 8, "note": "Industrial and brachytherapy radioisotope. Supply is facility-dependent."},
    {"id": "si-28", "name": "Si-28", "type": "Isotope", "val": 10, "note": "Enriched silicon for quantum materials. Limited by separation capacity."},
    {"id": "o-18", "name": "O-18", "type": "Isotope", "val": 9, "note": "Stable isotope feedstock used to produce F-18. Critical upstream input for PET supply."},
    {"id": "c-13", "name": "C-13", "type": "Isotope", "val": 8, "note": "Stable carbon isotope used in research, labeling, and selected industrial applications."},
    {"id": "n-15", "name": "N-15", "type": "Isotope", "val": 8, "note": "Stable nitrogen isotope used in research and tracer applications."},
    {"id": "b-10", "name": "B-10", "type": "Isotope", "val": 9, "note": "Neutron-absorbing boron isotope important in nuclear control materials and selected medical pathways."},
    {"id": "xe-129", "name": "Xe-129", "type": "Isotope", "val": 7, "note": "Stable xenon isotope used in imaging research and specialized applications."},
    {"id": "he-3", "name": "He-3", "type": "Isotope", "val": 10, "note": "Scarce helium isotope. Practical supply has mainly come from tritium decay recovery, not bulk helium production."},
    {"id": "li-6", "name": "Li-6", "type": "Isotope", "val": 11, "note": "Fusion-relevant lithium isotope. Enriched from natural lithium; feeds tritium breeding."},
    {"id": "li-7", "name": "Li-7", "type": "Isotope", "val": 7, "note": "Complement to Li-6 in nuclear chemistry and related systems."},
    {"id": "haleu", "name": "HALEU", "type": "Isotope", "val": 10, "note": "High-assay low-enriched uranium product. Depends on scarce enrichment above LEU."},
    {"id": "h-2", "name": "H-2 Deuterium", "type": "Isotope", "val": 8, "note": "Heavy hydrogen for research, moderators, and fusion-related use."},
    {"id": "h-3", "name": "H-3 Tritium", "type": "Isotope", "val": 9, "note": "Fusion fuel isotope linked to Li-6 breeding pathways and He-3 recovery."},
    {"id": "reactor-production", "name": "Reactor production", "type": "Process", "val": 13, "note": "Neutron-based isotope creation. Backbone of medical isotope supply."},
    {"id": "accelerator-production", "name": "Accelerator production", "type": "Process", "val": 10, "note": "Charged-particle routes for medical and research isotopes."},
    {"id": "cyclotron-production", "name": "Cyclotron production", "type": "Process", "val": 9, "note": "Local accelerator route for short-lived medical isotopes such as F-18."},
    {"id": "radiochemical-processing", "name": "Radiochemical processing", "type": "Process", "val": 10, "note": "Separation, purification, and product preparation between irradiation and usable isotope products."},
    {"id": "gas-centrifugation", "name": "Gas centrifugation", "type": "Process", "val": 13, "note": "Industrial isotope separation by mass. Core enrichment method."},
    {"id": "laser-enrichment", "name": "Laser enrichment", "type": "Process", "val": 9, "note": "Optical isotope separation pathway for selected uranium and specialty isotope applications."},
    {"id": "haleu-enrichment", "name": "HALEU enrichment", "type": "Process", "val": 9, "note": "Enrichment pathway toward HALEU product. Capacity is limited."},
    {"id": "tritium-breeding", "name": "Tritium breeding", "type": "Process", "val": 9, "note": "Converts Li-6 pathways into tritium for fusion fuel concepts."},
    {"id": "he3-recovery", "name": "Tritium decay recovery", "type": "Process", "val": 9, "note": "Helium-3 recovered as tritium decays and is processed."},
    {"id": "uranium-conversion", "name": "Uranium conversion", "type": "Process", "val": 10, "note": "Converts uranium concentrates into UF6 feedstock for enrichment plants."},
    {"id": "precision-medicine", "name": "Precision Medicine", "type": "Application", "val": 14, "note": "Imaging and targeted radiotherapy that depend on isotope supply."},
    {"id": "quantum-technologies", "name": "Quantum Technologies", "type": "Application", "val": 12, "note": "Needs ultra-pure or rare isotopes such as Si-28 and He-3."},
    {"id": "nuclear-fusion", "name": "Nuclear / Fusion", "type": "Application", "val": 13, "note": "Depends on enriched materials, breeding routes, and nuclear infrastructure."},
    {"id": "industrial-uses", "name": "Industrial Uses", "type": "Application", "val": 11, "note": "Sterilization, radiography, tracers, and other industrial applications that depend on selected radioisotopes and stable isotopes."},
    {"id": "hfir", "name": "HFIR", "type": "Facility", "val": 8, "note": "High Flux Isotope Reactor at Oak Ridge. Major U.S. high-flux node for specialty medical and industrial isotopes."},
    {"id": "murr", "name": "MURR", "type": "Facility", "val": 8, "note": "University of Missouri Research Reactor. Important U.S. medical isotope irradiation site, including Mo-99 related work."},
    {"id": "atr", "name": "ATR", "type": "Facility", "val": 7, "note": "Advanced Test Reactor, Idaho. High-power irradiation capability."},
    {"id": "mcmaster", "name": "McMaster", "type": "Facility", "val": 7, "note": "Canadian university reactor with isotope production activity."},
    {"id": "br2", "name": "BR2", "type": "Facility", "val": 7, "note": "Belgian research reactor. Core European irradiation node for Mo-99 and other medical isotopes."},
    {"id": "hfr-petten", "name": "HFR Petten", "type": "Facility", "val": 7, "note": "Netherlands high-flux reactor. Key European node for Mo-99 and Lu-177 irradiation supply."},
    {"id": "frm-ii", "name": "FRM II", "type": "Facility", "val": 7, "note": "German research reactor supporting neutron research and isotope-related work."},
    {"id": "ill", "name": "ILL", "type": "Facility", "val": 6, "note": "Institut Laue-Langevin neutron source in Grenoble."},
    {"id": "lvr-15", "name": "LVR-15", "type": "Facility", "val": 6, "note": "Czech research reactor supporting irradiation and isotope-related work."},
    {"id": "opal", "name": "OPAL", "type": "Facility", "val": 7, "note": "Australian research reactor supporting large-scale Mo-99 production for domestic and export supply."},
    {"id": "hanaro", "name": "HANARO", "type": "Facility", "val": 6, "note": "South Korean research reactor with irradiation capability."},
    {"id": "dhruva", "name": "Dhruva", "type": "Facility", "val": 6, "note": "Indian research reactor node with isotope production relevance."},
    {"id": "carr", "name": "CARR", "type": "Facility", "val": 6, "note": "Chinese advanced research reactor node."},
    {"id": "jrr-3", "name": "JRR-3", "type": "Facility", "val": 6, "note": "Japanese research reactor supporting neutron and isotope-related work."},
    {"id": "safari-1", "name": "SAFARI-1", "type": "Facility", "val": 7, "note": "Pelindaba research reactor. Key Southern Hemisphere medical isotope production node linked to NTP."},
    {"id": "riar", "name": "RIAR", "type": "Facility", "val": 7, "note": "Dimitrovgrad complex. Major Russian isotope production node."},
    {"id": "maria", "name": "MARIA", "type": "Facility", "val": 6, "note": "Polish research reactor contributing to isotope production capacity."},
    {"id": "ra-3", "name": "RA-3", "type": "Facility", "val": 6, "note": "Argentine research reactor supporting regional isotope production."},
    {"id": "etrr-2", "name": "ETRR-2", "type": "Facility", "val": 6, "note": "Egyptian research reactor node."},
    {"id": "iea-r1", "name": "IEA-R1", "type": "Facility", "val": 6, "note": "Brazilian research reactor supporting research and isotope-related activity."},
    {"id": "hfetr", "name": "HFETR", "type": "Facility", "val": 7, "note": "Chinese high-flux reactor used for isotope production including industrial and medical pathways."},
    {"id": "oklo-groves", "name": "Oklo Groves", "type": "Facility", "val": 7, "note": "Isotope test reactor in Lockhart, Texas. Pathway toward domestic isotope production capability."},
    {"id": "bruce-ips", "name": "Bruce Power IPS", "type": "Facility", "val": 7, "note": "Power-reactor isotope production system for Lu-177 and Co-60."},
    {"id": "darlington", "name": "Darlington", "type": "Facility", "val": 7, "note": "Power-reactor pathway for Mo-99 related production."},
    {"id": "cnl-chalk-river", "name": "CNL Chalk River", "type": "Facility", "val": 7, "note": "Canadian isotope research and Ac-225 related production node."},
    {"id": "rsg-gas", "name": "RSG-GAS", "type": "Facility", "val": 6, "note": "Indonesian research reactor supporting regional isotope production."},
    {"id": "blip", "name": "BLIP", "type": "Facility", "val": 7, "note": "Brookhaven accelerator isotope production node."},
    {"id": "triumf", "name": "TRIUMF", "type": "Facility", "val": 7, "note": "Canadian accelerator centre with isotope production capability."},
    {"id": "lanl-ipf", "name": "LANL IPF", "type": "Facility", "val": 6, "note": "Los Alamos Isotope Production Facility."},
    {"id": "arronax", "name": "ARRONAX", "type": "Facility", "val": 6, "note": "French accelerator facility focused on medical radioisotope production."},
    {"id": "psi", "name": "PSI", "type": "Facility", "val": 6, "note": "Paul Scherrer Institute. Swiss accelerator-based isotope node."},
    {"id": "ithemba", "name": "iThemba LABS", "type": "Facility", "val": 6, "note": "South African accelerator facility with isotope production capability."},
    {"id": "shine-janesville", "name": "SHINE Janesville", "type": "Facility", "val": 8, "note": "U.S. commercial site with live Lu-177 production and a developing Mo-99 pathway outside traditional reactor dependence."},
    {"id": "northstar-beloit", "name": "NorthStar Beloit", "type": "Facility", "val": 7, "note": "Accelerator-based production focused on Cu-67 and Ac-225."},
    {"id": "nusano-utah", "name": "Nusano", "type": "Facility", "val": 7, "note": "Multi-isotope cyclotron production facility in Utah."},
    {"id": "anl-leaf", "name": "ANL LEAF", "type": "Facility", "val": 7, "note": "Argonne electron-accelerator facility for medical isotope production."},
    {"id": "ire-fleurus", "name": "IRE Fleurus", "type": "Facility", "val": 8, "note": "Belgian radioisotope processing hub. Major Mo-99 processing and distribution node tied to European irradiation capacity."},
    {"id": "itm-neufahrn", "name": "ITM Neufahrn", "type": "Facility", "val": 8, "note": "Large dedicated n.c.a. Lu-177 production facility near Munich. Important processing node in the therapeutic supply chain."},
    {"id": "centrus-piketon", "name": "Centrus ACP", "type": "Facility", "val": 8, "note": "Piketon enrichment site. Central to U.S. advanced enrichment and HALEU pathway development."},
    {"id": "urenco-usa", "name": "Urenco USA", "type": "Facility", "val": 8, "note": "Eunice, New Mexico commercial uranium enrichment plant."},
    {"id": "urenco-almelo", "name": "Urenco Netherlands", "type": "Facility", "val": 7, "note": "Almelo enrichment plant."},
    {"id": "urenco-uk", "name": "Urenco UK", "type": "Facility", "val": 7, "note": "Capenhurst enrichment plant."},
    {"id": "urenco-de", "name": "Urenco Deutschland", "type": "Facility", "val": 7, "note": "Gronau enrichment plant."},
    {"id": "orano-tricastin", "name": "Orano GBII", "type": "Facility", "val": 8, "note": "Georges Besse II at Tricastin."},
    {"id": "novouralsk", "name": "Novouralsk UEIP", "type": "Facility", "val": 7, "note": "Russian commercial enrichment site."},
    {"id": "zelenogorsk", "name": "Zelenogorsk ECP", "type": "Facility", "val": 7, "note": "Russian commercial enrichment site."},
    {"id": "seversk", "name": "Seversk SCC", "type": "Facility", "val": 6, "note": "Russian enrichment / fuel-cycle site."},
    {"id": "angarsk", "name": "Angarsk AECC", "type": "Facility", "val": 6, "note": "Russian enrichment site."},
    {"id": "lanzhou", "name": "Lanzhou Enrichment", "type": "Facility", "val": 6, "note": "Chinese enrichment site."},
    {"id": "hanzhong", "name": "Hanzhong Enrichment", "type": "Facility", "val": 6, "note": "Chinese enrichment site."},
    {"id": "rokkasho", "name": "JNFL Rokkasho", "type": "Facility", "val": 6, "note": "Japanese enrichment site."},
    {"id": "resende", "name": "INB Resende", "type": "Facility", "val": 6, "note": "Brazilian enrichment site."},
    {"id": "rattehalli", "name": "RMP Rattehalli", "type": "Facility", "val": 6, "note": "Indian enrichment site."},
    {"id": "asp-pretoria", "name": "ASP Pretoria", "type": "Facility", "val": 7, "note": "Specialty isotope enrichment site in Pretoria. Focused on selected stable and nuclear-related isotope pathways."},
    {"id": "savannah-river", "name": "Savannah River Site", "type": "Facility", "val": 7, "note": "DOE site associated with tritium processing pathways relevant to He-3 recovery."},
    {"id": "metropolis-conversion", "name": "Metropolis conversion", "type": "Facility", "val": 7, "note": "Key U.S. commercial uranium conversion context for UF6 feedstock."},
    {"id": "bellwether-lab", "name": "Bellwether Lab", "type": "Facility", "val": 7, "note": "TerraPower Isotopes Ac-225 manufacturing project in Philadelphia."},
    {"id": "urenco", "name": "Urenco", "type": "Company", "val": 8, "note": "Major commercial enricher with plants in Europe and the U.S."},
    {"id": "centrus", "name": "Centrus Energy", "type": "Company", "val": 7, "note": "U.S. enrichment company focused on advanced enrichment and HALEU."},
    {"id": "orano", "name": "Orano", "type": "Company", "val": 7, "note": "Fuel-cycle company including major commercial enrichment capacity."},
    {"id": "asp-isotopes", "name": "ASP Isotopes", "type": "Company", "val": 7, "note": "Specialty isotope enrichment company with Pretoria facilities."},
    {"id": "quantum-leap-energy", "name": "Quantum Leap Energy", "type": "Company", "val": 8, "note": "ASP Isotopes subsidiary focused on nuclear fuel-cycle pathways including uranium conversion, HALEU-oriented enrichment work, and lithium isotope separation."},
    {"id": "silex", "name": "Silex", "type": "Company", "val": 7, "note": "Laser enrichment technology company."},
    {"id": "framatome", "name": "Framatome", "type": "Company", "val": 7, "note": "Nuclear fuel and technology company."},
    {"id": "curium", "name": "Curium", "type": "Company", "val": 7, "note": "Major radiopharmaceutical company across diagnostic and therapeutic chains."},
    {"id": "lantheus", "name": "Lantheus", "type": "Company", "val": 7, "note": "Medical imaging and radiopharmaceutical company."},
    {"id": "northstar", "name": "NorthStar", "type": "Company", "val": 7, "note": "Medical isotope company focused on Cu-67 and Ac-225 accelerator production after exiting Mo-99."},
    {"id": "itm", "name": "ITM", "type": "Company", "val": 7, "note": "Radiopharmaceutical company active in therapeutic isotope development and supply."},
    {"id": "telix", "name": "Telix", "type": "Company", "val": 7, "note": "Radiopharmaceutical company focused on diagnostic and therapeutic nuclear medicine."},
    {"id": "novartis", "name": "Novartis", "type": "Company", "val": 7, "note": "Pharmaceutical company with radioligand therapy programs."},
    {"id": "bayer", "name": "Bayer", "type": "Company", "val": 7, "note": "Pharmaceutical company with targeted radionuclide therapy activity."},
    {"id": "terrapower-isotopes", "name": "TerraPower Isotopes", "type": "Company", "val": 8, "note": "Expanding Ac-225 supply, including a large Philadelphia manufacturing project."},
    {"id": "shine", "name": "SHINE", "type": "Company", "val": 7, "note": "Medical isotope company with Lu-177 production and non-traditional Mo-99 pathways."},
    {"id": "nusano", "name": "Nusano", "type": "Company", "val": 7, "note": "Radioisotope production company building medical isotope capacity."},
    {"id": "pantera", "name": "PanTera", "type": "Company", "val": 7, "note": "Focused on Ac-225 production scale-up."},
    {"id": "niowave", "name": "Niowave", "type": "Company", "val": 7, "note": "Accelerator-based medical isotope company including Ac-225 related supply."},
    {"id": "orano-med", "name": "Orano Med", "type": "Company", "val": 7, "note": "Orano nuclear medicine arm focused on targeted alpha therapy."},
    {"id": "ire", "name": "IRE", "type": "Company", "val": 7, "note": "Belgian radioisotope producer important to Mo-99 supply."},
    {"id": "nrg", "name": "NRG", "type": "Company", "val": 7, "note": "Operator context around Petten research reactor irradiation and isotope-related services."},
    {"id": "polatom", "name": "POLATOM", "type": "Company", "val": 6, "note": "Polish radioisotope producer linked to MARIA reactor pathways."},
    {"id": "invap", "name": "INVAP", "type": "Company", "val": 6, "note": "Argentine nuclear technology company connected to research reactor and isotope infrastructure development."},
    {"id": "kaeri", "name": "KAERI", "type": "Company", "val": 6, "note": "Korea Atomic Energy Research Institute context around HANARO and national nuclear research capacity."},
    {"id": "circ", "name": "CIRC", "type": "Company", "val": 6, "note": "China Isotope & Radiation Corporation, major Chinese isotope and radiation products organization."},
    {"id": "jsc-isotope", "name": "JSC Isotope", "type": "Company", "val": 6, "note": "Russian isotope trading and supply organization connected to national production capacity."},
    {"id": "artms", "name": "ARTMS", "type": "Company", "val": 6, "note": "Technology company focused on cyclotron-based medical isotope production routes."},
    {"id": "isotopia", "name": "Isotopia", "type": "Company", "val": 6, "note": "Radiopharmaceutical and isotope company active in therapeutic isotope supply."},
    {"id": "sofie", "name": "SOFIE", "type": "Company", "val": 6, "note": "Radiopharma company connected to PET manufacturing activity."},
    {"id": "bwxt", "name": "BWXT", "type": "Company", "val": 7, "note": "Nuclear manufacturer with isotope-related nuclear work."},
    {"id": "eckert-ziegler", "name": "Eckert & Ziegler", "type": "Company", "val": 7, "note": "Radiopharmaceutical and isotope technology company."},
    {"id": "ansto", "name": "ANSTO", "type": "Company", "val": 7, "note": "Australian nuclear science organization with OPAL-related radioisotope production."},
    {"id": "ntp", "name": "NTP", "type": "Company", "val": 7, "note": "South African radioisotope producer linked to SAFARI-1."},
    {"id": "iba", "name": "IBA", "type": "Company", "val": 6, "note": "Accelerator technology company connected to nuclear medicine infrastructure."},
    {"id": "convertdyn", "name": "ConverDyn", "type": "Company", "val": 6, "note": "U.S. uranium conversion joint venture context."},
    {"id": "doe-isotope-program", "name": "DOE Isotope Program", "type": "Company", "val": 8, "note": "U.S. program coordinating isotope production and distribution across national laboratory capabilities."}
  ],
  "links": [
    {"source": "mo-99", "target": "reactor-production", "relation": "produced_by"},
    {"source": "mo-99", "target": "precision-medicine", "relation": "used_in"},
    {"source": "mo-99", "target": "radiochemical-processing", "relation": "requires"},
    {"source": "mo-100", "target": "mo-99", "relation": "supplies"},
    {"source": "mo-100", "target": "accelerator-production", "relation": "related_to"},
    {"source": "lu-177", "target": "reactor-production", "relation": "produced_by"},
    {"source": "lu-177", "target": "precision-medicine", "relation": "used_in"},
    {"source": "lu-177", "target": "radiochemical-processing", "relation": "requires"},
    {"source": "ac-225", "target": "accelerator-production", "relation": "produced_by"},
    {"source": "ac-225", "target": "precision-medicine", "relation": "used_in"},
    {"source": "ac-227", "target": "ra-223", "relation": "supplies"},
    {"source": "ac-227", "target": "precision-medicine", "relation": "related_to"},
    {"source": "th-228", "target": "pb-212", "relation": "supplies"},
    {"source": "th-228", "target": "precision-medicine", "relation": "related_to"},
    {"source": "pb-212", "target": "precision-medicine", "relation": "used_in"},
    {"source": "at-211", "target": "cyclotron-production", "relation": "produced_by"},
    {"source": "at-211", "target": "precision-medicine", "relation": "used_in"},
    {"source": "ra-223", "target": "precision-medicine", "relation": "used_in"},
    {"source": "y-90", "target": "reactor-production", "relation": "produced_by"},
    {"source": "y-90", "target": "precision-medicine", "relation": "used_in"},
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    {"source": "sr-89", "target": "reactor-production", "relation": "produced_by"},
    {"source": "sr-89", "target": "precision-medicine", "relation": "used_in"},
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    {"source": "sm-153", "target": "precision-medicine", "relation": "used_in"},
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    {"source": "ho-166", "target": "precision-medicine", "relation": "used_in"},
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    {"source": "cu-64", "target": "accelerator-production", "relation": "produced_by"},
    {"source": "cu-64", "target": "precision-medicine", "relation": "used_in"},
    {"source": "zr-89", "target": "accelerator-production", "relation": "produced_by"},
    {"source": "zr-89", "target": "precision-medicine", "relation": "used_in"},
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    {"source": "c-11", "target": "precision-medicine", "relation": "used_in"},
    {"source": "xe-133", "target": "reactor-production", "relation": "produced_by"},
    {"source": "xe-133", "target": "precision-medicine", "relation": "used_in"},
    {"source": "tb-161", "target": "reactor-production", "relation": "produced_by"},
    {"source": "tb-161", "target": "precision-medicine", "relation": "used_in"},
    {"source": "i-131", "target": "reactor-production", "relation": "produced_by"},
    {"source": "i-131", "target": "precision-medicine", "relation": "used_in"},
    {"source": "f-18", "target": "cyclotron-production", "relation": "produced_by"},
    {"source": "f-18", "target": "precision-medicine", "relation": "used_in"},
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    {"source": "co-60", "target": "industrial-uses", "relation": "used_in"},
    {"source": "co-60", "target": "precision-medicine", "relation": "used_in"},
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    {"source": "ir-192", "target": "precision-medicine", "relation": "used_in"},
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    {"source": "si-28", "target": "quantum-technologies", "relation": "used_in"},
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    {"source": "o-18", "target": "precision-medicine", "relation": "used_in"},
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    {"source": "n-15", "target": "industrial-uses", "relation": "used_in"},
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    {"source": "b-10", "target": "industrial-uses", "relation": "used_in"},
    {"source": "xe-129", "target": "precision-medicine", "relation": "used_in"},
    {"source": "xe-129", "target": "industrial-uses", "relation": "used_in"},
    {"source": "he-3", "target": "quantum-technologies", "relation": "used_in"},
    {"source": "he-3", "target": "he3-recovery", "relation": "produced_by"},
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    {"source": "he3-recovery", "target": "savannah-river", "relation": "located_at"},
    {"source": "li-6", "target": "gas-centrifugation", "relation": "enriched_by"},
    {"source": "li-6", "target": "tritium-breeding", "relation": "requires"},
    {"source": "li-6", "target": "nuclear-fusion", "relation": "used_in"},
    {"source": "li-7", "target": "nuclear-fusion", "relation": "used_in"},
    {"source": "h-2", "target": "nuclear-fusion", "relation": "used_in"},
    {"source": "h-3", "target": "tritium-breeding", "relation": "produced_by"},
    {"source": "h-3", "target": "nuclear-fusion", "relation": "used_in"},
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    {"source": "haleu", "target": "nuclear-fusion", "relation": "used_in"},
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    {"source": "reactor-production", "target": "hfir", "relation": "located_at"},
    {"source": "reactor-production", "target": "murr", "relation": "located_at"},
    {"source": "reactor-production", "target": "atr", "relation": "located_at"},
    {"source": "reactor-production", "target": "mcmaster", "relation": "located_at"},
    {"source": "reactor-production", "target": "br2", "relation": "located_at"},
    {"source": "reactor-production", "target": "hfr-petten", "relation": "located_at"},
    {"source": "reactor-production", "target": "frm-ii", "relation": "located_at"},
    {"source": "reactor-production", "target": "ill", "relation": "located_at"},
    {"source": "reactor-production", "target": "lvr-15", "relation": "located_at"},
    {"source": "reactor-production", "target": "opal", "relation": "located_at"},
    {"source": "reactor-production", "target": "hanaro", "relation": "located_at"},
    {"source": "reactor-production", "target": "dhruva", "relation": "located_at"},
    {"source": "reactor-production", "target": "carr", "relation": "located_at"},
    {"source": "reactor-production", "target": "jrr-3", "relation": "located_at"},
    {"source": "reactor-production", "target": "safari-1", "relation": "located_at"},
    {"source": "reactor-production", "target": "riar", "relation": "located_at"},
    {"source": "reactor-production", "target": "maria", "relation": "located_at"},
    {"source": "reactor-production", "target": "ra-3", "relation": "located_at"},
    {"source": "reactor-production", "target": "etrr-2", "relation": "located_at"},
    {"source": "reactor-production", "target": "iea-r1", "relation": "located_at"},
    {"source": "reactor-production", "target": "hfetr", "relation": "located_at"},
    {"source": "reactor-production", "target": "oklo-groves", "relation": "located_at"},
    {"source": "reactor-production", "target": "bruce-ips", "relation": "located_at"},
    {"source": "reactor-production", "target": "darlington", "relation": "located_at"},
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    {"source": "reactor-production", "target": "rsg-gas", "relation": "located_at"},
    {"source": "accelerator-production", "target": "blip", "relation": "located_at"},
    {"source": "accelerator-production", "target": "triumf", "relation": "located_at"},
    {"source": "accelerator-production", "target": "lanl-ipf", "relation": "located_at"},
    {"source": "accelerator-production", "target": "arronax", "relation": "located_at"},
    {"source": "accelerator-production", "target": "psi", "relation": "located_at"},
    {"source": "accelerator-production", "target": "ithemba", "relation": "located_at"},
    {"source": "accelerator-production", "target": "shine-janesville", "relation": "located_at"},
    {"source": "accelerator-production", "target": "northstar-beloit", "relation": "located_at"},
    {"source": "accelerator-production", "target": "nusano-utah", "relation": "located_at"},
    {"source": "accelerator-production", "target": "anl-leaf", "relation": "located_at"},
    {"source": "radiochemical-processing", "target": "ire-fleurus", "relation": "located_at"},
    {"source": "radiochemical-processing", "target": "itm-neufahrn", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "centrus-piketon", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "urenco-usa", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "urenco-almelo", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "urenco-uk", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "urenco-de", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "orano-tricastin", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "novouralsk", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "zelenogorsk", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "seversk", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "angarsk", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "lanzhou", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "hanzhong", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "rokkasho", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "resende", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "rattehalli", "relation": "located_at"},
    {"source": "gas-centrifugation", "target": "asp-pretoria", "relation": "located_at"},
    {"source": "haleu-enrichment", "target": "centrus-piketon", "relation": "located_at"},
    {"source": "uranium-conversion", "target": "metropolis-conversion", "relation": "located_at"},
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    {"source": "silex", "target": "laser-enrichment", "relation": "supplies"},
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    {"source": "centrus", "target": "centrus-piketon", "relation": "operates"},
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    {"source": "orano", "target": "orano-tricastin", "relation": "operates"},
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    {"source": "asp-isotopes", "target": "asp-pretoria", "relation": "operates"},
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    {"source": "quantum-leap-energy", "target": "li-6", "relation": "supplies"},
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    {"source": "framatome", "target": "haleu", "relation": "supplies"},
    {"source": "framatome", "target": "nuclear-fusion", "relation": "supplies"},
    {"source": "convertdyn", "target": "metropolis-conversion", "relation": "operates"},
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    {"source": "lantheus", "target": "precision-medicine", "relation": "supplies"},
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    {"source": "itm", "target": "itm-neufahrn", "relation": "operates"},
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    {"source": "itm", "target": "precision-medicine", "relation": "supplies"},
    {"source": "telix", "target": "precision-medicine", "relation": "supplies"},
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    {"source": "terrapower-isotopes", "target": "ac-225", "relation": "supplies"},
    {"source": "terrapower-isotopes", "target": "precision-medicine", "relation": "supplies"},
    {"source": "terrapower-isotopes", "target": "bellwether-lab", "relation": "operates"},
    {"source": "shine", "target": "shine-janesville", "relation": "operates"},
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    {"source": "nusano", "target": "nusano-utah", "relation": "operates"},
    {"source": "nusano", "target": "accelerator-production", "relation": "supplies"},
    {"source": "nusano", "target": "precision-medicine", "relation": "supplies"},
    {"source": "pantera", "target": "ac-225", "relation": "supplies"},
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    {"source": "niowave", "target": "ac-225", "relation": "supplies"},
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    {"source": "orano-med", "target": "precision-medicine", "relation": "supplies"},
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    {"source": "ire", "target": "ire-fleurus", "relation": "operates"},
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    {"source": "ire", "target": "precision-medicine", "relation": "supplies"},
    {"source": "nrg", "target": "hfr-petten", "relation": "operates"},
    {"source": "nrg", "target": "reactor-production", "relation": "supplies"},
    {"source": "polatom", "target": "maria", "relation": "related_to"},
    {"source": "polatom", "target": "mo-99", "relation": "supplies"},
    {"source": "invap", "target": "ra-3", "relation": "related_to"},
    {"source": "invap", "target": "reactor-production", "relation": "related_to"},
    {"source": "kaeri", "target": "hanaro", "relation": "related_to"},
    {"source": "kaeri", "target": "reactor-production", "relation": "related_to"},
    {"source": "circ", "target": "precision-medicine", "relation": "supplies"},
    {"source": "circ", "target": "industrial-uses", "relation": "supplies"},
    {"source": "jsc-isotope", "target": "riar", "relation": "related_to"},
    {"source": "jsc-isotope", "target": "precision-medicine", "relation": "supplies"},
    {"source": "artms", "target": "cyclotron-production", "relation": "supplies"},
    {"source": "artms", "target": "mo-99", "relation": "related_to"},
    {"source": "isotopia", "target": "lu-177", "relation": "supplies"},
    {"source": "isotopia", "target": "precision-medicine", "relation": "supplies"},
    {"source": "sofie", "target": "f-18", "relation": "supplies"},
    {"source": "sofie", "target": "precision-medicine", "relation": "supplies"},
    {"source": "bwxt", "target": "reactor-production", "relation": "supplies"},
    {"source": "bwxt", "target": "precision-medicine", "relation": "supplies"},
    {"source": "eckert-ziegler", "target": "precision-medicine", "relation": "supplies"},
    {"source": "eckert-ziegler", "target": "lu-177", "relation": "supplies"},
    {"source": "ansto", "target": "opal", "relation": "operates"},
    {"source": "ansto", "target": "mo-99", "relation": "supplies"},
    {"source": "ansto", "target": "precision-medicine", "relation": "supplies"},
    {"source": "ntp", "target": "safari-1", "relation": "related_to"},
    {"source": "ntp", "target": "mo-99", "relation": "supplies"},
    {"source": "ntp", "target": "precision-medicine", "relation": "supplies"},
    {"source": "iba", "target": "cyclotron-production", "relation": "supplies"},
    {"source": "iba", "target": "precision-medicine", "relation": "related_to"},
    {"source": "doe-isotope-program", "target": "hfir", "relation": "related_to"},
    {"source": "doe-isotope-program", "target": "blip", "relation": "related_to"},
    {"source": "doe-isotope-program", "target": "lanl-ipf", "relation": "related_to"},
    {"source": "doe-isotope-program", "target": "anl-leaf", "relation": "related_to"},
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    {"source": "hfetr", "target": "co-60", "relation": "related_to"},
    {"source": "hfetr", "target": "ir-192", "relation": "related_to"},
    {"source": "rsg-gas", "target": "precision-medicine", "relation": "related_to"},
    {"source": "shine-janesville", "target": "mo-99", "relation": "related_to"},
    {"source": "itm-neufahrn", "target": "lu-177", "relation": "supplies"},
    {"source": "ire-fleurus", "target": "mo-99", "relation": "supplies"},
    {"source": "bruce-ips", "target": "lu-177", "relation": "supplies"},
    {"source": "bruce-ips", "target": "co-60", "relation": "supplies"},
    {"source": "darlington", "target": "mo-99", "relation": "related_to"},
    {"source": "cnl-chalk-river", "target": "ac-225", "relation": "supplies"},
    {"source": "oklo-groves", "target": "precision-medicine", "relation": "related_to"},
    {"source": "anl-leaf", "target": "cu-67", "relation": "related_to"}
  ]
}